Ways to lengthen telomers. Temmeter elongation suspends aging. However, such factors should be remembered.

Our body is designed for life in 120 years. The resource "counts" parts of DNA - telomeres. That is, to slow down the aging process, it is enough to take care of the state of the telomere. How to read further.

Telomeres are repetitive DNA sequences that are at the ends of chromosomes. With each division, the cells telomeres are shortened. Over time, they are very "erased", which leads to the aging of the cell, and then - to her death. The accumulation of such cells in the body increases the risk of developing diseases. According to the theory of the heiflica limit, the potential life expectancy of a person is 120 years. To this age, too many cells are becoming too many cells that are not able to share and maintain its livelihood.

The telomerase enzyme restores shortened DNA. In an adult, he is almost inactive. But it has a high activity in the cells of embryos and malignant tumors.

Why Strait Stress

Many harmful age-related age changes are associated with shortening telomere. First of all, these are diseases of the heart, obesity, diabetes and degeneration of cartilage fabric. According to research, people with short telomeres get tired quickly, their wrinkles appear early and often have colds.

Life expectancy directly depends on stress: the more people are nervous, the more intense the telomeres are shortened. This, in turn, accelerates the biological aging of cells. Chronic stress and depression mean a poor state of telomere, their exposure to premature shortening. This is the main reason that stress is old man.

Basic nutrition for telomere

Recover telomeres helps the telomerase enzyme. The activity of this enzyme can be activated by moderate physical exertion, as well as balanced nutrition, which includes vitamins and polyunsaturated fatty acids. Moreover, studies argue that the length of the telomere in people leading correct image Life, much more, what those who abuse alcohol do not follow their nutrition and weight, leads a low-effective lifestyle.

The length of the telomer can also be maintained using nutrition, since the most important processes will not pass if the body is lack of vitamins B6, B12 and folic acid.

The daily diet must necessarily include proteins, especially sulfur-containing. Do not do without dairy products, eggs, meat, chicken, legumes, nuts and cereals. Eggs are especially important because they are the richest source of choline. And to restore damage to DNA, magnesium and zinc are required.

Power is an excellent mechanism for slowing the wear of the body if food has a sufficient amount of antioxidants. These are biologically active substances that protect cells from oxidation. The most famous and affordable antioxidants are vitamins C and E. By providing the body with antioxidants, you not only protect the cells and slow down the aging, but also output yourself from the Ryk group.

Used photos Depositphotos

You can get special anti-aging creams, paint your hair or even buy some medicines, but it does not change the situation as a whole. Can we slow down the course of the cell clock?

Aging is not something that can be seen outside. This is a process that occurs on the microscopic level. Fortunately, cells can slow down this process.

Cell division occurs in our body constantly

This is necessary to replace old, damaged cells new. One of the manifestations of aging is the slowdown and termination of cell divisions, as a result of which the body begins to fade.

It is believed that aging is associated with the terminal areas of DNA. They are like "protective caps" at the ends of chromosomes. The same as plastic tips, holding the ends of the shoelaces so that they do not break down on the thread.

With each division of cells, telomeres are shortened. Therefore, the longer the telomers, the more divisions waiting for the cells in front, and the old age retreats.

Here are some factors that affect the length of the telomere and our age.

Proper nutrition

Photo: pexels.com/kaboompics // Karolina / CC0 License

Since we are older, our immune system also weakens. T-lymphocyte blood protector cells lose their properties, which makes us more vulnerable to diseases, from colds to cancer.

The decrease in the functions of T cells is associated with the P38 Mark molecule, according to researchers from the University College of London.

The block P38 Mark stimulates the activity of T cells and enhances their potential to divide. The good news is that the P38 Mark activated with low consumption nutrients. That is, to avoid aging lymphocytes and impairment of immunity, it is necessary to eat correctly.

Physical activity increases the potential of mitochondria

Physical activity not only good way Avoid diseases of civilization, but also a means of aging, however, with a small reservation. Researchers from the Mayo clinic found that fast food can accelerate the aging of cells in mice, and physical activity Slow down.

Physical activity increases the potential of mitochondria, energy stations in cells. Exercises increase both the amount of mitochondria and their activity.

However, it is not necessary to abuse redundant loads. Superimensional physical exertion can accelerate the metabolism and cell division.

According to Dr. Joel Furman, the activation of metabolism is important for weight loss. But at the same time, it leads to premature aging.

Weight loss can add cells of life

According to American Society For Metabolic and Bariatric Surgery, obesity has an adverse effect on health, causes premature aging and reduces life expectancy.

Even the treatment of obesity surgically led to an increase in the length of the telomere. If telomeres become longer, you make old age.

Meditation

Want to go back to carefree childhood days? Researchers from American College of Physicians found that regular classes The meditation led to a decrease in cell stress indicators of 1.7%.

Stress control is an important step to fight aging, since stress shortens the length of the telomere and causes systemic inflammation in the body.

Medicinal herbs

Some sources claim that the Chinese ginger, Ginkgo Biloba and the extract of the astragal root favorably affect the telomere state. Extracts of these plants were able to reduce the number of immune cells with short telomeres.

However, in some cases, researchers had material interest in the results of experiments, reports Rodale News.

Get up and idi

In fact, most things that we do sitting do not deserve so much time.

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Each cell division requires copying its DNA. For this, the DNA polymerase enzyme is responsible.

He resembles a train:moves along the rails in the form of a double spiral of DNA and the "letter beyond" reproduces its nucleotide sequence, manufacturing an identical molecule that remains next to the original.

However, the DNA polymerase has a significant drawback. For reasons, to deepen into which there is no need, the entire DNA molecule of this enzyme is never copied.

In other words, with each cell division, its small plot is lost, and the copied chain turns back to the original. The end of the chromosome is gradually "bodied."

The second problem arising from chromosomes is their tendency to often ride due to the action of radiation and other adverse factors. The cell has to sew the resulting scraps. At the same time, of course, it in no case should be confused with the ends of intact chromosomes, and, therefore, it must somehow distinguish between these two types of DNA sections.

Partly such a problem is solved by nature with telomere. These terminal sections of chromosomes do not contain genetic information, representing monotonous reversals of the short sequence of nucleotides. Their shortening in multiple DNA copies and cell divisions does not cause any harm to the body - while telomers remain long enough. However, it is not necessary to fear its complete disappearance, since there is a telomerase enzyme, which lengthens this meaningless terminal sequence of DNA.

More precisely, he decides at once two problems. On the one hand, the cells expressing the telomerase restore their telomeres attractive with each division and can share indefinitely. On the other hand, the telomer preservation does not allow the mechanism that eliminates DNA breaks, sewing different chromosomes: meaningless end repeats are recognized by the corresponding enzymes and are left alone.

People and some other species are witty use of this telomocreterase system to protect against cancer. Malignant cells kill the body only after multiple division. Without telomerase, it is impossible: if the telomeres are not recovered, they will gradually disappear, the ends of chromosomes, having ceased to differ from intrachromosomic breaks, in the end, will be connected, and as a result cancer cells At a minimum will not be able to share more. Therefore, the genes encoding the gements in them as far as possible are disconnected.

To restore the activity of this enzyme and, accordingly, the ability of cancer cells to the division would require a lot of very "successful" mutations. Although this issue has been studied less, in older carriers cytomegalovirus (CMV) There is also an excess of defective CD4 lymphocytes, called T-HELLERs, which help other components of the immune system to organize a counteroffensive to the pathogens penetrated into the body. In other words, these externally healthy people occur the same clonal expansion aimed at CMW, but the CD28 CD4 cells devoid of the CD28 receptor, as in their CD8 population. The result is a similar oarsaturation by specialized lymphocytes that are not reacting to activate antigen-presenting cells.

Not activating them, these defective T-helpers do not fulfill their function, i.e. Do not make mobilization to combat the enemy of CD8-lymphocytes and other immune cells. Such a situation - along with the inability of T-killers mentioned above, it effectively attacks its targets - gives a cytomegalovirus to reproduce freely. This leads to additional clonal expansions and further aggravation of immune dysfunction.

Clonally propagated CMV-specific CD8 cells aergent (ineffective) and from other points of view. With the first infection of the mouse version of this virus, young mice produce very active T-killers that recognize at least 24 of its antigens. However, when the infection becomes chronic, their special forces aimed at CMV are reduced to clones that respond to an average of only five such proteins. In addition, in older people with cytomegalovirus, the aell CD8 cells react to the virus weaker than that of its young carriers, producing significantly less than gamma interferon, one of the most important chemical ammunological response amplifiers.

Poor commander of good armies

Probably, the inability of the aergent T-lymphocytes to deal with the CMV infection leads to many other typical immunological dysfunctions for older people, which cannot be explained by any direct effect of the aging of these cells. Some of these effects could be expected in connection with the change in the production of cytokines affecting the activity of other fighters of congenital and adaptive parts of the immune system, but others cause much more resistant consequences than just problems with chemical alarm.

For example, according to the widespread now, the aging of T cells explains the age reduction in the effectiveness of B-lymphocytes, synthesizing the antibodies to foreign antigens and thus weighing pathogens as a target for destruction by other cells. For ripening and generating antibodies in cells, signals are needed from T-helpers, therefore proof that the old age of T cells causes a decrease in the effectiveness of the B-lymphocytic system, independent of its own aging, was only a matter of time.

Unfortunately, no one has yet figured out whether such an effect is due to cytomegalovirus induced by T-lymphocytes, which plays a crucial role in the development of other aspects of the aging of their population. As a result, we do not know how much effects on B-cells such a specific phenomenon, as the aellization of T cells.

Even if you get distracted from mechanistic explanations and molecular biological mechanisms, the real impact of a crawling ottaching of the entire immune system, the aerger CD8-clones on human health becomes apparent when studying the specific results of this process. Animal experiments show that the age-related clonal expansion of individual CD8 subpopulations reduces the diversity of T cells present in the body, and in the end, and their ability to ensure effective immune defense. Examples of similar effects from our species - the deterioration in the CD8 response to influenza vaccinations and the weakening of the T-cell immunity against the Epstein-Barr virus in people with the clonal expansion of the CMW-specific memory cells.

Counting losses

Even if the effects on the organism of the clones of the aell T-lymphocytes were limited to an increase in morbidity and mortality from infectious diseases, we had enough reasons to desire to get rid of these cells. However, there is quite a good reason to believe that they also contribute to the age of weakening the organism that does not find an obvious immunological explanation.

First of all, in the elderly victims of influenza or pneumonia provoked by it, there are surprisingly long consequences, significantly accelerating other pathological processes and the movement of a person towards senile helplessness, and ultimately in the cemetery. According to many data, the influenza suffered in solid age increases the risk of death from unexpected causes of the type of myocardial infarction and stroke, as well as from as if not related to this infection of respiratory diseases; In addition, the flow of stagnant heart failure is sharp.

Further, such a long recovery of biologically old people from influenza, imposing on their general weakness due to other aspects of aging, probably contributes to serious, often life-long functional degradation and disabled. The flu often stacked an elderly person to the hospital, sometimes for three more weeks, and studies show that every day of bed regime means a loss of up to 5% of muscle strength and 1% aerobic endurance. However, seeing how a woman with difficulty opens the door or, slipping on ice, breaks her neck of the thigh, no one thinks about his cold or immunological aging.

You can also recall other senile illness, in the development of which, apparently, the clones of the aergeric T-cells play a significant role, but evidence of this is not so obvious. One of these pathologies is osteoporosis. Elderly women with osteoporotic fractures found more high levels Aergic CD8 cells than their peers with healthy bones. At the same time, some molecular mechanisms suggest that the abundance of such defective lymphocytes is precisely the cause, and not by the consequence of the decrease in the density and strength of bone tissue.

In addition, despite the comparative speculativity of this assumption, the clarization of the T-cell population could even affect the course of atherosclerosis. It leads to a chronic inflammatory process, which is known to spoil the arteries, contributing to the emergence of myocardial infarction. In favor of this hypothesis, there is higher than in healthy people, the level of aell CD8 cells in patients with coronary heart disease - both at CMV infection and its absence. Thus, the weakening of the immune system is, apparently, as a facilitant factor and the result of infectious damage to the arteries, which in turn favors the development of atherosclerosis with all its potential consequences.

As already mentioned, the exact evidence of the coupons of the aeric clones of T-cells with these remote effects is not yet available. However, a couple of interesting research in the framework of the European Union of Project T-kis (T-cell immunity and aging)Already brought us closer to a clearer assessment of the death role of this cause of age immunodeficiency - that would ultimately be written in the death certificate.

These studies concerned two cohort of the "oldest" residents of Sweden, i.e. Those who for 80 and 90, and covered only people practically healthy compared to most of their chronological peers: with a lack of serious heart disease, brain, liver and kidney, without cancer, diabetes, signs of active infections or chemical markers Inflammation and not taking any drugs noticeably operating on the immune system, including recent vaccinations.

European scientists have discovered several people with a complex of hidden immunological defects among these relatively healthy old people ("phenotype of immune risk"), for example various forms Age lesion, which can be explained by cytomegalovirus infection, and therefore, to no less and clone expansion of the aegic CMW-specific CD8 cells.

The fact that some representatives of the studied healthy, despite the greater chronological old age (according to modern standards), the samples were free from the clones of the aergic T cells, allowed to trace their "pure" effect in a subgroup where the presence of such lymphocytes could really contribute to developing in the next two years of diseases, and not result.

No one surprised the result of observations:the phenotype of immune risk, as was supposed, increased the likelihood of ambulance, but the scale of such an influence was shocked. It was especially pronounced in the group of people over 90, where this deficit allowed to explain 57% of mortality. We remind: We are talking about the age-related weakening of the immune system caused by the virus, whose activity is not observed by many of us at all, and in other cases it is usually felt only as a slight ailment with temperature increase.

It is important to correctly understand the entire value of this discovery. The phenotype of immune risk contributed to all causes of mortality, and not only increased the risk to die from infectious disease. Although the external pathogens, indeed, kill many biologically old people, microbial attacks explain the results are far from completely.

War against clones

As the data speaking the role of CMV-specific CD8-cell clones in the age weakening of the immunity, the bright side of this phenomenon began to be opened. If immunological aging is explained in such a significant extent explained by the expansion of T-lymphocytes, it means that its warning, and even more so the appeal must be reversed (respectively) to protect or restore the young state of the immune system, regardless of our chronological age. So, vaccines will act on the old people as efficiently as on the youth. And the elderly will reset the inbox of infections, from which young people get rid of, just a couple without looking at school or to work.

One of the prevention options supported by many immunologists is vaccination against cytomegalovirus. Even before the central role of CMV infection in the age weakening of the immune system, published in 1999 Medical Institute The US National Academy, noting the unsatisfactory pace of development of new vaccines, put the creation of an effective anti-CMV vaccine in the first place in the list of urgent tasks. We emphasize that the authors of the report proceeded only from the information accumulated by the time of the human and financial losses caused by this virus.

Later, the National Vaccination Agency under the Vaccination Program, coming to the same conclusion, requested the government additional means On research in the field of vaccine against cytomegalovirus. Now, when clear evidence is obtained by the important role of the CMV infection in the aging of the immune system, many experts speak out for a further increase in these allocations.

Although the benefits of this approach and look indisputable, it is worth recalling that it is mainly about the preventive strategy. It will reduce the risk of CMV infection and, perhaps, will strengthen the immune response to it already infected people, but will not save them from the virus and, of course, will not eliminate the accumulated long years His presence of immunological damage.

Therefore, such a vaccine will save a relatively small percentage of infants from severe innate defects and prevents the missing death of many patients with AIDS and patients with transplanted bodies, but almost will not improve the status of hundreds of millions of people who are already suffering from chronic infections and increased sensitivity to pathogens due to the weakening of immune Systems of clonal expansion of the aergeric CD8 cells.

Other suggestions, at least potentially eliminating some aspects of immunological aging, are associated with an attempt to treat defects of already existing aneergic T-cell methods of gene therapy. The idea is that the supply of these lymphocytes with genes encoding their lost or insufficiently active proteins (for example, a CD28 receptor or telomerase) would allow to restore the effectiveness of their specific tasks and prevent the oppression of other T-cell populations. Although such an approach and looks logical, it is too limited, and the clinical development path is too foggy.

As for specifically, telomerase, the consequences of its activation in any cell cause many more questions and require more serious consideration. These doubts are associated with another age pathology - cancer. Since at least a tiny telomer is necessary to continue divisions, each of which shortens it, cells with potentially carcinogenic mutations for transformation into a malignant tumor requires a telecom recovery mechanism.

Almost all cancer cells launch it, breaking their own brakes from telomerase genes. Is it worth providing defective cells with these genes, especially considering the risk of random "infection" by the genotherapeutic vectors of "foreign" cells, in which in no case cannot be included with telomerase?

A more legitimate solution does not look like the rehabilitation of inactive lymphocytes, but their destruction. The elderly carriers of the cytomegalovirus, apparently, lacking functional T-killers aimed at the cells infected with this virus. The cause of such a deficiency is the abundance of the body with huge subpopulations of the aell lymphocytes. Even if we manage to return to all of them full immunological competence, they will create a problem, still limiting the resources necessary to preserve naive lymphocytes and memory cells necessary to protect against other pathogens.

Theoretically, everything looks simple. Getting rid of the aerygic T-clones, we liberate the immunological space for healthy cells of other types and specializations, including for both active lymphocytes aimed at CMV.

It remains to solve the question: How to cleanse the body from the broken idlers, leaving all of all (or at least all) their hostages, which we want to get rid of Tuneev's oppressors. Oncologists are already quite effective and not too harmful to the body as a whole drug and radiation methods for the destruction of relatively large tumors in specific areas of the body, however, this approach is not applicable in the case of aergic T cells, not concentrated in separate places, but distributed by various tissues and organs .

For the same reason, it is useless to talk about surgery. The tumor can be cut (or at least cut), having achieved with a certain risk of a particular clinical improvement. However, in the near future, no ways of individual surgical removal of the aegic T-cells are foreseen.

Nevertheless, despite the non-applicability of traditional anticancer methods as a sample to develop the biotechnology necessary for us, the last impressive success of oncologists suggest the idea of \u200b\u200bthe principal possibility of therapy that ensures the electoral deliverance of the body from not wanting to die cells.

Aroma Glinem

Even if none of your friends are sick with cancer, you could well hear about Gillis (STI-571, or Imatinib), Ires (ZD1839, or Gephitinibe), Hercetty (Trastuzumab) and other less well-known or still launching the path to sick medications the same Groups. We are talking about the so-called "aiming anti-cancer therapy", which is considered to be a revolutionary innovation. Even the formulation of the type of "wonderful healings" is absurd often used in popular medical literature, it does not seem to be exaggerated by those who personally observed the disappearance of malignant tumors in their own body or in the body of their loved ones, without facing the most severe side effects of irradiation and chemotherapy.

Of course, these medicines also give side effects - no "violating metabolism" is not free from them. For example, Herceptin is aimed at Her-2's growth receptor: binding it, it prevents uncontrolled reproduction of cancer cells, which is stimulated by an excess of the copies of this receptor on their surface. However, normal cells multiply "as it should", too, thanks to the HER-2-stimulation, only relatively weak.

And as a result, the use of hrycentine can cause deadly stagnant heart failure - by-effectwhich recent studies also found in some patients using the Gleem, who was considered a highly harmless medicine - precisely because it was aimed only for an abnormal form of one of the transductors of growth signals.

Similarly, affecting the stability of the aegic T-lymphocytes to apoptosis, it would be possible to stimulate their "suicide", but the question remains: how not to destroy normal cells?

These funds do not give effect while they do not have a certain low-energy laser irradiation, which for its part does not affect people who have not received such medicines: the rays without any harm pass through their body. However, when they penetrate the cells that accumulated photodynamic medicine, its properties lead to their sharp warming or saturation of free radicals. As a result, these cancer cells are dying, and all others (not counting in close proximity) do not suffer.

The first PDT agent, PhotoFrine, was admitted to developed countries for the treatment of a far-seated lung cancer, digestive tract and urinary tract in early 1990s. Now used or are in the final development stage of more advanced options for such therapy.

The most promising of its funds, RS-4, selectively accumulates in certain types of cancer cells, since it is well soluble in fats, which are especially rich in these cells. Penetrating in them, RS-4 due to the peculiarities of their structure are embedded in mitochondria. Subsequent laser irradiation launches a free radical bombing, which either induces apoptosis, or - in the worst case - kills cancer cells "dirty way", stitching their proteins, oxidizing lipid membranes, destroying DNA mutations.

Get access to the codes of "youth"? Not a problem! Unless we are ready for "oddities", paradoxics and (oh, horror!) - To our inadequateness super body.

Strange begins when we learn that in general, our cognitive breakdowns are prevented by the search and awareness of the codes of "youth."

Neurobiologists soothe: "You can cope with this oddity if you treat yourself with self-irony. Our super body At the brain level, it often behaves "not super". Brain Rebuilt against objective reality and novelty. But with this you can work! ".

Not so long ago, a "bomb" appeared in the English-speaking segment of the Internet. Scientists presented a huge list of our cognitive distortion, or, easier, - breakdowns.

How to accept such a revelation: We often visit the illusion that some things we do very correctly and logically, but in fact - the opposite is the opposite? But such perception is manifested in all spheres of life. Actually, it greatly complicates our access to the codes of "youth." Scientists represent proven facts, and we do not perceive. But finally, they perceived: "Hurray! It turns out that rejuvenation at the cellular level - in our hands! ". And in five minutes - forgot. New knowledge scattered - it "swallowed" a cognitive breakdown!

"It's not worth upset, it is fixable! First, it is necessary to accept the fact that the brain sometimes distorts objective reality, and secondly, it is not afraid to get acquainted with these distortions. The more we know about them, the more they lose their strength, "neurobiologists reassure us.

On the main codes of "youth" it is necessary to speak differently, and more often. This is not quite simple information. And any complexity of the brain "does not like", because it is forced to spend energy on her development and memorization. Therefore, he in every way he sees from it, displacing from the memory what we want to invest.

One of the main codes of "youth" - telomeres. What telomeres? No, this is not something, measuring the body! This is the terminal section of DNA, or, in other words, the terminal sections of chromosomes. Our body consists of cells that are able to share by creating their own copies. At first glance, it seems that if the cells are constantly updated, the body can live forever. But this is unreal. The most important part of the cell is chromosome, they contain information about the cell. When dividing the cell, chromosomes are also divided by creating a copy of all the necessary information. At the tips of chromosomes and are telomers.

Telomers under a microscope - highlighted areas

Our aging begins when Telomeres Start shortening. Beyond the aging means - do not give them to shorten in the "natural" rhythm. Stop fully shuffling telomere- It is impossible, and suspend - quite! And this is already a very great achievement in our commissioning " eternal youth».

Why can not completely stop the reduction of telomere? Because this process is laid down by the program itself. So that our life continues, cells must share. For our entire life, each cell is divided about 50 times. This is the border of life! With each division of cells, telomerers are shortened. Procurement telomer - and there is the most accurate marker of aging. If the doctor who does not know our age and appearance will look in our laboratory telomeres, He will definitely determine our age. So:

• The first (outstanding) reason for shortening telomer is the very time of our stay on Earth.
• Second (Removing) Cause telomere - Stress.
• Third (Removing) Cause telomere - unhealthy food.

Two reasons for shortening telomerewhich we can control are already very much to achieve enchanting results. Here they are the same 20-25 extra ages of adult freshness, which we can quite afford.

More recently, scientists believed that Telomers are shortened irreversible - and they cannot be increasing them. And most of us did not know anything at all about the telomeres - "stressed", ate "staring" food, and, as a result, hopelessly "burned" their telomers.

Now it is no longer so. It turns out, size telomer You can partly increase back. For the proof of this "mysterious" properties telomer In 2009, the Nobel Prize was awarded to American scientists Elizabeth Blackburn, Carol Grader and Jack Shostaku. In our superteller there is an enzyme - telomerase, which, in fact, lengthens our telomers. Now telomerase can be perceived as a rejuvenating "cream" produced by our super supervision. It is he who provides the "super-threat" effect "youth from the inside". The work of this "cream" is intensified at times, if we are able to manage stress and go to the rejuvenating food.

How Liz Jones increased her telomeres

Famous journalist Liz Jones Share his story, as for some couple of years aged for a decade. "Never, never, never repeat my mistake!", - turns to us Liz. Liz (full name - Elizabeth Ann Jones) -Britan journalist, Russian version of Ksyushi Sobchak in a "diluted form".

She worked at The Sunday Times and "Evening Standard", was the "Marie Claire" editor. Now leads speakers in "Daily Mail" and "The Mail on Sunday", writes for "High Life Magazine". Some years ago Lizthe prize "Observer of the Year" was noted.

Liz He is enthusiastically read, follow her life, love and hate, consider a talented journalist, but a complex person. She writes about the injustices of the world, about the fashion industry, about poor animals, about diverse social problems, with knowledge of the case taught on " clean water» Kim Kardashian and Victoria Beckham..

That Liz Care the questions of "eternal youth", no one could think! So, Joneshe spoke about aging, how she overnight was covered by the "wave of aging", and how she reflected this wave. At the time Liz turned 57 years old. She led a bright lifestyle: in demand on all fronts, a lot of readers, awards, "Funny Plans." With this formation, aging seemed clean abstraction. It all arranged, and not even spoiling appearance. Decorative cosmetics I. children's glances The world is its main rejuvenation tools at the time.

But at some point everything went wrong. Lizdivorced with husband. She wanted intellectual romance - move from London to a small town and writing books among pastoral hills. Taking a large loan Liz Acquired a huge house with a plot of land. But soon the house seemed too large and uncomfortable, the climate is too raw and cold, and life is lonely and terrible. But the biggest problem was the payment of a loan. Distance from parents, friends and colleagues at work also made himself felt. She died appetite, sleep, and even the ability to relax.

But the peak of the crisis came when Lizbecause of the vehicle breakdown, I was late for an important business meeting. And then the nervous "spring" shot! "I felt that I had to go to the limit: I could not live so much, could not even breathe - and burst out! After an hour of waiting for help, I accidentally glanced in the rearview mirror - the tow truck came to me. Oh no! Oh God! My heart fell! From the mirror I watched an old, battered woman, with a sagging, gray face and huge bags under the eyes.

I instantly came awareness - my wrong choice, my cognitive "glitches" pulled old age! For some three years I have been so aged! "

Left Liz Jones with normal telomeres,
right - with shortened

"Fix the situation!", - In such a rush, Liz simply rushed to the writer Taa Singer,which at that time released the book "Reduch stress - rejuvenate the body and soul." The book described about a super study conducted by two very talented women - already mentioned Elizabeth Blackburn (Nobel laureate) and Elissa Ebel (a leading psychiatrist scholar). The importance of this work is difficult to overestimate. The authors associate our aging with stress and suggest, as, driving stress and lifestyle, can be "repaired" appearance, rejuvenate all organism systems.

This is especially important for women, as they, due to increased emotion, are more susceptible to stress than men. "And with the inevitable colossal stress of women begin to face aged 40+. The body begins hormonally rebuilding, grown children - rebel, elderly parents - to hurt, husbands - to pass the middle-aged crisis, and in the career of age competition intensifies. Stress is seized by unhealthy food, and the circle closes.

Stress especially accelerates our course. When my daughter became a teenager, our relationship spoiled. For me, it turned out to be a stressful "tsunami". Care for sick parents is almost always buried women! In women who care for patients with children or parents, telomeres are shortened sharply. But they increase as soon as women enter the lane of positive and spiritual well-being, "says TEA Singler.

The same "secret" cream

"My mother did not go to the fitness center, did not make the epilation, did not drive the car and did not know how to sign a check, - until dad died. She always looked tumaled, elegant and well-groomed, unlike modern non-working housewives, which for some reason constantly lacks time. It's striking that my mother contained his house in a brilliant state, despite the fact that almost all the work did manually, and today's housewives with a million gadgets do not have time, "- the edit LizAnd continues, "Mom was equilibrium! She and her working girlfriends knew nothing about the level of stress, with whom we live today. They moved a lot, worked in the garden, ride a bike ... "

It has been proven that the active movement promptly removes the stress hormones from the blood, which means that DNA is not damaged, and telomers are not shortened. It is the hormones of stress shortening telomeres. That's why fitness is so important!

When stressing in the blood, a cortisol hormone is ejected, which "eats" telomers, and, it means, accelerates aging. But it becomes not only "bad" stress, Izmohes and "good" stress, in which adrenaline hormone is thrown into the blood. An exciting meeting, a long-awaited event, a wedding, moving to a new place ... - All this causes blind feelings and refers to good stress. We get a tide of energy, tone rises. But if the delight does not leave us for a long time, adrenaline does not fall, - we are exhausting and declared. It is necessary to cool and come to balance.

Equilibrium in a pair with deep mental well-being "increasing" telomers, - aging is inhibited. We bloom again!

Now Liz Jones You can call an expert for long youth. It has been maning stress quite well, can read a whole lecture on the distortions of our brain. Actually, our cognitive distortions are in most cases and lead to stress: we make mistakes. Liz acquired stress resistance. Getting into a car traffic jam, she smiles and includes music. Takes a chelated form that stimulates the growth of telomeres. We get vitamins of chelated form from food, and not from pharmacy drugs. At girlfriends Lizwho, like she herself, take Omega -3 from flax seeds, - telomeres are longer than those who do not do this.

"From stress not going anywhere - this is an indispensable part of our lives, but it is necessary to react to them in a new way. You need to increase your stress resistance constantly, "says Liz- "At some point we begin to make terrible mistakes and drive themselves into stress." Today there is a mass of methods under stress resistance. And back Liz Combines telephone conversations and serials with homemade fitness or dancing. And it does it with great pleasure. "The keyword here is with pleasure," she clarifies.

Usually in women in gym The face and neck is tense. This suggests that the girls in the pursuit of the super supervisor do without pleasure. In this case, bad stress hormones are thrown into the blood. Poor OUR telomeres! And it should be on the contrary - if the exercises bring pleasures, then the hormones in the blood will throw positive.

And, of course, sleep! As the strongest regulator super body, he never fails if we are not opposed to him.

Is it worth trying new drugs for extension telomere?

Today in the best laboratories of the world are looking for artificial decisions on the extension of temometer, clinical studies are underway. Such solutions even appeared on the market. Many scientists advise not in hurry to acquire the drug with an impeverate effect. The fact is that molecular medicine is a relatively young direction. There was still relatively little time since the search for artificial buildups began telomere. For medical preparations, a long time is returned to check. Not much accumulated knowledge about the intricacies of this process.

It is beneficial to rely on the proven, the natural path that wisely is laid in our body from the beginning of centuries. This is advised to us by scientists from the University of California in San Francisco, who conducted a study on the natural elongation of telomere. For five years, people who have moved to healthy food, at least 30 minutes a day walked on fresh air, a complex of light exercises did not dispel, the length of the telomer rose by an average of 10%. For those who behaved the usual way of life, telomeresreducing.

Output: Not knowing anything about our telomerees, we are making tremendous harm - literally "for the ears" attract our old age. The longer our longer telomers The longer we stay young and healthy. Telomeresreduced from stress and unhealthy food, and lengthen again - from spiritual well-being, positive and rejuvenating, healthy eating.

In our super tele Superinstruments are already laid on rejuvenation without risks and cash spending. But possession of these tools still has its price, which is primarily in the change of thinking, without which neither stress resistance or healthy image Life is not achieved. And how to change thinking? We will get acquainted to begin with the list of our cognitive (brain) breakdowns, which I will try in the near future. And if we are on the principle of "little steps every day" something for the "best version of yourself", - our super body Does not roll.

All people are aging at different speeds. It is not difficult to determine the chronological age - it is enough to look into your passport.

The age of biological is more difficult to determine. This indicator reflects how rationally we use the genetic program we received at birth, and also characterizes the "degree of wear" of organs and systems of our body.

Despite the fact that the first age changes we note predominantly on external signs (condition of the skin, hair, figures and posture), aging processes are formed and developing inside - at the cellular level.

If the biological age is ahead of the calendar, the aging develops prematurely, the risk of diseases associated with age increases.

Let's look into the core of the cell and find the biological clock of aging.

Inside the nuclei there are 23 pairs of chromosomes and telomers are located at the ends of each chromosome. They protect our DNA as well as plastic tips protect the edges of the shoelaces.

Telomers:

• Do not bear genetic information
• Each cell of our body contains 92 telomers
• Play an important role in the process of cell division - ensure the stability of the genome
• Protect chromosome in the process of replication from degradation and merger
• Ensure the structural integrity of the endings chromosomes
• Protect cells from mutations, aging and death

While we are young, cells are effectively divided.

Every time a cell is divided, should be divided and chromosome, as a result of which telomers decrease.

Ultimately, telomeres become so short that they can no longer protect chromosomes. The cell agrees and can no longer perform its functions.

Is it possible to protect telomeres and stop aging?

Numerous scientific research allowed scientists to solve the secret of managing age and give a positive response to this question.

Telomerase is an amazing enzyme that is able to finish short telomeres. Thanks to Telomerase, aging cells of our body acquire the ability to share, like young, healthy cells.

• creates a matrix at which critically short telomeres
• prevents the shortening of telomere
• protects cells from aging
• prolongs the life of the cell
• allows the cell to return to the young phenotype, i.e. Function on the scenario of the young cage

• Short telomeres are associated with sharply pronounced age-related changes in health
• Long telomeres are associated with longevity.

To affect the biological clock of aging and launch the process of cellular rejuvenation, it is necessary to activate, i.e. "Turn on" telomerase.