Pentalgin appointment. Interaction with other medical preparations. Pentalgin and alcohol

Pentalgin is a combined drug from a group of non-selective NSAIDs (non-steroid anti-inflammatory drug), cyclooxygenase inhibitor (COF-1 and COF-2). The composition includes 5 substances that complement each other's actions: paracetamol, metamizole, phenobarbital, codeine and caffeine. Release form:

• Pentalgin-IC tablets, 10 tab. On the plate: paracetamol 200 mg, sodium metamizole (analgin) 300 mg, caffeine 20 mg, phenobarbital 10 mg and codeine 9.5 mg
• Pentalgin-ICN tablets, 12 tab. On the plate: paracetamol 300 mg, sodium metamizole (analgin) 300 mg, caffeine 50 mg, phenobarbital 10 mg and codeine 8 mg
• Pentalgin-FS tablets, 10 tab. On the plate: paracetamol 300 mg, sodium metamizole (analgin) 300 mg, caffeine 50 mg, phenobarbital 10 mg and codeine 8 mg

Indications for the use of Pentalgin

Pentalgin is shown in the following diseases of the spine and its structures:

• Spine tumor (both benign and malignant)
• Spinal injuries (injury, fracture, dislocation, etc.)
• Postoperative period

Contraindications

Pentalgin is contraindicated in the following diseases in the patient:

• Pregnancy
• Period lactation
• Children under 12
• Allergy to the drug and its constituents
• Recently transferred cranoping injury
• Anemia
• Increased intracranial pressure
• Glaucoma
• Episodes of bronchospasm of unexplained etiology
• Ulcer in the intestines and stomach
• Respiratory failure
• Liver failure
• Renal failure
• Diabetes
• Myocardial infarction, sharp period
• High arterial pressure numbers
• Insufficiency of glucose-6-phosphate dehydrogenase (hereditary congenital disease)
• Elevated nervous excitability
• Drowsiness day and insomnia at night
• Arrhythmia
• Bronchial asthma

Operating principle

The action of Pentalgin is based on the complementance of the components of the active substances. Paracetamol and metamizole belong to the NSAID with a non-selective blockade of COF-1 and COF-2, which makes it possible to stop the production of prostaglandins (inflammation mediators) and reduce pain and phenomenon phenomenon.

Phenobarbital has a slight sedative effect, and also removes spasm in the smooth muscles of vessels and transverse back muscles, enhances the action of the NSAID.

Caffeine stimulates the nervous system, speeds up the bloodstream and enhances the action of paracetamol and metamizole.

Codeine refers to narcotic analgesics, has pronounced painkillers and antitussive effects, enhances the effect of phenobarbital and NSAIDs.

As a result, the patient feels an instant reducing pain in the spine, after a few days of admission, the inflammation of the tissues and their swelling is reduced, the amplitude of active and passive movements in the back is restored, the patient returns to the familiar lifestyle, which led to the exacerbation of the disease.

Method of use Pentalgin

Pentalgin must be taken inside by drinking with enough liquid, 1-2 tablets 1-3 times per day. Reception along with food or in the first 15-20 minutes after meals, it improves the absorption of the drug in the gastrointestinal tract. Maximum daily dosage - 4-5 tablets. The course of treatment is up to 5 days. If necessary, you can extend treatment under the control of blood tests (overall analysis and liver samples) or repeat the incidence of the disease.

Side effects

Pentalgin side effects are rarely developing:

• Rash and itching on the skin
• Dry mouth
• Heartbeat (Tachycardia)
• Pain in the abdomen
• Reduced appetite
• Nausea
• Vomot
• Headache
• Shivering in hands
• Increased drowsiness
• Heart palpitations
• Constipation
• Worsening visual acuity
• Sweet Qincke (angioedema edema)
• Dizziness
• Eveny
• Renal failure
• Liver failure

All side effects of the use of pentalgin require the cancellation of the drug and the reception of symptomatic medicines.

In case of non-compliance with the prescribed dosage of Pentalgin and exceeding it several times, the development of signs of overdose is possible several times:

• Pronounced general weakness
• Strong nausea and vomiting
• Reduced arterial pressure
• Foreignness of breathing
• Pallor skin
• Arrhythmia
• Acute hepatic insufficiency
• Strong stomach pain
• Tachycardia (rapid heartbeat)

In the case of overdose, the pentalgin should urgently rinse the stomach, consult a doctor, take enterosorbents and symptomatic means.

special instructions

During the pregnancy of any period of gestation and during the feeding of the child, the reception of Pentalgin is strictly contraindicated due to the negative effect of the drug on the fruit and the infant (inhibits the respiration and formation of organs).

Children up to 12 years old, Pentalgin is not possible due to the possible oppression of the respiratory center.

Alcoholic beverages can reduce or disrupt the effect of the drug, cause the development of side effects, therefore it is recommended for 3 hours after receiving Pentalgin not to take alcohol. After the last reception of alcoholic beverages should also go from 2 to 8 hours (the stronger the drink, the longer it is necessary to withstand).

To date, pharmacological companies produce several species of the Pentalgin medicinal product - the composition of medicines in this case varies depending on the full name. The effectiveness of each of the drugs is estimated in accordance with the reasons that cause painful syndrome.

Composition of pentalgin tablets

The type of pain involved means is the only species that is released without a recipe. Its formula was recently improved in such a way as to eliminate pain not only due to inflammatory processes and nervous stresses, but also because of vascular spasms.

New or green pentalgin has the composition without Codein and:

• naproxen;
• dROTAVERIN;
• paracetamol;
• maleat of Phoeniramin;
• anhydrous caffeine.

The combination of these 5-components provides antispasmodic, anti-inflammatory, analgesic and light antipyretic effect.

It is important to note that the possibility of the non-receptible acquisition of such Pentalgin does not exclude the need to consult with the attending doctor. The fact is that the ingredients of the medication produce a mass of negative side effects, especially for the digestive and cardiovascular system. Moreover, the content of caffeine in high concentration provokes an increase in blood pressure, which is unacceptable for people suffering from hypertension.

The composition of Pentalgin Plus

This type of drug is distinguished by the content of additional analgesics - proppopenazone. This ingredient has low anti-inflammatory activity, but has obviously pronounced painkillers and antipyretic properties. The combination with the other components of the medication makes it possible to achieve the most quick effect even with very strong pain syndrome.

Full composition:

• codeine phosphate;
• phenobarbital;
• caffeine;
• propifenazon.

As a rule, the described type of pentalgin is prescribed for diseases and injuries of joints, muscles, infringement of the nerve, dental and headaches. Sometimes it is used to facilitate the symptoms of feverish syndrome.

Composition of Pentalgin-ICN

The presented form of the line of analgesics belongs to the anesthetic means of high intensity. The combination of active chemical compounds provides sustainable and rapid relief of pain syndrome even with chronic diseases of the cardiovascular and nervous system. Pentalgin-ICN successfully eliminates the clinical manifestations of migraine, smooth muscles spasms.

The drug consists of the following ingredients:

• sodium metamizole;
• codeine phosphate;
• paracetamol;
• caffeine;
• phenobarbital.

Like the previous type of Pentalgin, the drug considered is released exclusively in the presence of a recipe written by the doctor.

The composition of Pentalgin N or Neo

The latter form of the drug is produced without paracetamol. Such pentalgin has excellent antispasmodic and analgesic properties, but has a less pronounced anti-inflammatory and antipyretic activity. This is carried out due to the inclusion in the composition of the naproxen - non-steroidal substance with high painful indicators.

Currently there are many new drugs. Some of them are released by pharmacies without a doctor's prescription, others - strictly by recipe. It is useful to people to find out what pentalgin tablets are presented - instructions for use, as the medicine acts, in what cases it helps whether it is possible to give it to children, which there are caution.

What is Pentalgin

The form of the drug is in the form of tablets. In the photo Pentalgin tablets (Pentalgin) are capsules covered with a shell of green embossed. Green tablets cut, sometimes with white splashes. Pentalgin fans in cell contour packages 2, 4, 12 tablets. External packaging - cardboard box. Buy Pentalgin in the pharmacy can be without a doctor's prescription. The shelf life of the tablets is two years from the date of manufacture, keep the drug is necessary in a dry, unlit place.

From which Pentalgin helps

The drug has a combined pharmacological action: anti-break; antipiretic (lowers temperature, relieves inflammation); antispasmodic action. Pentalgin helps to eliminate painful syndrome of various nature:

• in the joints, muscles;
• tooth, headache;
• in the spasome of the smooth muscles of the internal organs;
• postoperative inflammation;
• symptomatic with feverish states during colds.

From dental pain

A good result is achieved when Pentalgin is used for dental pain. The drug due to the combined pharmacological action simultaneously relieves pain and struggles with the inflammatory pulp process. The effect is achieved after half an hour after receiving a medicinal product, but if the medicine did not help, it should not be increased. It is necessary to refer to the Dentist for the treatment of inflammation.

From headache

The drug is an opposing agent. Doctors recommend to use pentalgin when headaches. With migraine, the drug has the ability to expand blood vessels, which helps to improve the blood supply and health of the patient. The effect of painful syndrome is increased by blocking the drug receptors of pain, so Pentalgin received positive feedback in the fight against headache.

With menstruation

The occurrence of pain at the bottom of the abdomen during the algodismenhery (menstruation) is associated with excessive synthesis of prostaglandins: they cause a reduction in the uterus, a small pelvis vessel spasm. Because of the stagnation of the tissue, oxygen is not allowed, and this is the cause of the excitation of pain receptors. Pentalgin from pain during menstruation removes pain syndrome by regulating the synthesis of prostaglandins, reduce the frequency of contraction of the muscles of the uterus and by blocking pain receptors.

From temperature

Effective is the use of pentalgin in colds. It helps to eliminate all the symptoms for influenza, angina: normalize temperature, fight inflammation in the body and remove pain syndrome for feverish states. The combined effect of the drug is the reason that doctors are often prescribed pentalgin at temperatures.

Pentalgin instructions

The drug is produced by the manufacturer with annotation to use it. Instructions for the use of Pentalgin preparation contains:

• description of pharmacological properties;
• information on active and auxiliary substances that are part of the drug;
• the list of states of the patient when the drug can be used;
• caution on side effect, which can occur when using the drug;
• contraindications for use.

Structure

The combined effect of Pentalgin is due to the properties of five active substances. The composition of pentalgin in tablets depends on the variety of drug. The manufacturer produces a drug with four names: This allows you to choose a suitable drug under the individual sensitivity of a person to analgesics. The Pentalgin of all four species necessarily includes paracetamol.

He begins to anesthetize, affecting the centers of thermoregulation and pain, removes spasm. Together with painful, anti-inflammatory, antipyretic effect. In combination with paracetamol, the manufacturer applies other active substances. The Pentalgin additionally includes four substances whose names are listed in the instructions. The active elements of the drug together with paracetamol can be:

1. Naproxen This nesteroid substance regulates the synthesis of prostaglandins, which are responsible for the contraction of the muscles. It removes spasm, inflammation, lowers the temperature.
2. Caffeine. It has a property to expand blood vessels, increases the activity of the brain, relieves the signs of fatigue, drowsiness, increases the effect of other painful substances.
3. Drochloride hydrochloride. Removes the spasm of smooth muscles of the genitourinary system, gastrointestinal tract, biliary tract, blood vessels.
4. Pheniramin Maleat. It blocks the synthesis of histamine, has a sedative effect, struggling with inflammatory processes. The substance removes spasm, increases the effect of paracetamol and naproxen.
5. Propifenazon.
6. Codeine. He is a narcotic element. Affects opioid receptors and changes the perception of pain. Reduces the degree of excitation of the center responsible for the cough, enhances the effect of anti-inflammatory, sedatives. Prolonged use may cause drug dependence.
7. Phenobarbital. Refers to barbiturates, increases paracetamol and metamizole parcetamol.
8. Sodium metamizol. Nonteroid preparation, has an painful effect.

Indications for use

The drug instruction contains recommendations when you can use tablets. Indications for the use of Pentalgin are as follows:

• with pain in the muscles and bones caused by arthralgia, Malgia, Neuralgia, Algodismenoria, Migraine, Bekhterev's disease, radiculitis, rheumatoid arthritis, spinal hernia;
• with pains that are caused by spasm, with diseases: chronic cholecystitis, gall-eyed disease, renal colic;
• after the operation, in case of pain and inflammation;
• with chills, high temperatures, inflammatory process with colds.

Dosage

How to take Pentalgin? The instruction contains the limit regulations for the reception of the drug. The dosage of Pentalgin is one tablet for half an hour before or after eating with the use of a large amount of water, the daily rate is three tablets, in special cases four. It is necessary to observe the interval of four hours between drug intakes. When using the drug to normalize the temperature, the course of treatment is three days, to remove the paint pain, it is not recommended to apply longer than five days. The duration of treatment, the number of techniques is set by the doctor.

Side effects

The instruction warns that there is a risk of reaction to the use of drugs by domestic organs and systems. Side effects of Pentalgin may be such:

• allergic manifestations in the form of a skin ferry, rash, urticaria;
• changes in the composition of blood, anemia;
• the increase in heartbeat, arrhythmia, an increase in blood pressure;
• dizziness, increased excitation, anxiety, sleep disorder, decline in attention;
• pain in the area of \u200b\u200bthe stomach, diarrhea, nausea, constipation, vomiting, loss of appetite;
• reducing hearing, acuteness, noise in the ears;
• violation of liver and kidney activities.

Contraindications

People can not drink medicine independently, because there are contraindications to the use of Pentalgin:

• increased sensitivity, allergies to active substances;
• pregnancy;
• lactation period for breastfeeding child;
• children under the age of 12;
• gastrointestinal bleeding;
• serious renal impairment, renal failure;
• paroxysmal tachycardia;
• hypertension;
• diabetes;
• oppression of bone marrowing;
• oppression of breathing, asthma;
• myocardial infarction.

It is not recommended to use tablets when taking other drugs, because in combination with other active substances, the toxicity of the drug may increase or decrease the effect of the drug. It is forbidden to use pentalgin and alcohol, it is impossible to take tablets while driving control, because they reduce attention. It is necessary to carefully take Pentalgin to senior people, patients with viral hepatitis, alcoholic damage to the liver, with epilepsy.

Pentalgin is an anesthetic drug. Prescribed with all sorts of pain syndromes, colds, painfully occurring periods. It is also used in migraine, dental pain, irregular states. Such an extensive number of possibilities of the drug is explained by the fact that it includes 5 actors at once. How and who can apply this drug, you can learn from the instructions for use.

Structure

The main drug substances are (mg):

• Paracetamol (324.83);
• Caffeine (40);
• Naproxen (90);
• Pheniramine (15);
• DROTAVERINA (35).

Also present:

• Sodium Croskarmelloz (321);
• Starch (55.40);
• Hypolosis (32.65);
• Yellow acid (2);
• Povidone (3.65);
• As well as minor inclusions of other components.

Forms of release

Sold in cell packs, 2-12 tablets in a pack.

Manufacturers Countries:

• BelMEDPreparations (Belarus);
• Tomskhimfarm (Russia).

International name: Pentalgin.

Storage conditions

Store in a dry, dark place at a temperature not higher than 23 ° C.

Dosage

Use one tablet after meals. On a day, you can take no more than 4 pieces of the drug.

Doses cannot be increased. In the absence of improvements, you need to immediately consult a doctor.

Indications

Indications for use:

Pentalgin from cough

Suitable for the treatment of cough, but only as an auxiliary. Take 2-3 tablets per day after meals. This is prohibited by the use of the drug during more than 3 days. Before use, you should consult with your doctor.

Pentalgin from migraine

Pentalgin will help from migraine, but it is too strong medicinal. With headaches, it is better to use a but-shlu or tamipul. It is advisable to consult a neurologist from a neurologist. It should also be understood that not everyone, for various reasons, can approach this drug.

Pentalgin during dental pain

The duration of the course depends on the complexity of the situation. It is advisable not to use more than 1 tablets per day. Treatment time - 3 days. It should be used only by appointing a dentist's doctor.

Pentalgin and alcohol

Alcohol consumption is strictly prohibited. The effect of phenobarbital substance increases, which can cause nervous disorders, brain coma (extremely rare). Also, the combination of alcohol and at once 5 active substances (codeine, caffeine, naproxen, sodium metamizole and phenobarbital) negatively affects the work of the liver and kidneys.

Pentalgin during pregnancy

Pentalgin use is prohibited during pregnancy. It is impossible to use the drug and when breastfeeding. Activity Codeine can get into the fruit, which will cause various defects and complications. It is also possible to add to the drug.

Pentalgin during menstruation

With painfully occurring periods, pentalgin can be used. Most women and girls advise to take this medicinal product in critical days. However, if the pain is not very strong, it is better to take a but-snap or any other painkiller, since Pentalgin is a sufficiently strong drug. This drug should be used only in extreme cases.

How does Pentalgin act?

Pentalgin consists of 5 active substances, which determine its effectiveness:

1. Naproxen Substance of the type of propionic acid. It acts antipyretically and anesthetically. It is used in the treatment of arthritis and other rheumatic ailments, diseases of the musculoskeletal system, as well as with a dysmanifier and strong gout.
2. Drochloride hydrochloride. Miotropic spasmolitic. By chemical structure and pharmacological properties similar to papaverine, but has a stronger and long effect.
3. Paracetamol. It is a total-spaced central nonarcotic analgesic, which has sufficiently fastened anti-inflammatory properties. Antipyretic and analgesic action.
4. Caffeine. It is a psychostimulator. Caffeine can be found in plants such as coffee tree, cocoa, mate, guarana, cola. Normalizes blood circulation, raises the tone.
5. Pheniramin Maleat. Penetrating the body, the substance goes along with blood flow. The greatest concentration is fixed after an hour after use. Soothes, has an anesthetic effect.

Contraindications

Pentalgin, like other drugs has a lot of contraindications. It:

Pentalgin should be taken with increased caution to those who have:

• Diabetes;
• Epilepsy.

Side effects

Overdose

Symptoms:

If one of these symptoms is detected, you need to immediately consult a doctor. This is especially true of elderly people.

• Washing the stomach with the subsequent use of activated carbon within 5 days (minimum);
• Administration of acetylcysteine;
• Use of antacid agents.

Treatment - only after inspection and according to the recommendations of the doctor.

Other instructions

It is necessary to avoid the use of Pentalgin together with drugs in which:

• Paracetamol;
• Barbiturates (reduce the effect of paracetamol);
• Ethanol (increases the risk of pancreatitis).

With these compounds, the risk of hepatotoxic influence increases.

Also avoid alignment with:

• Antidepressants;
• Medications from colds (drops, antipyretic means).

During treatment, care must be taken when driving. Pentalgin contributes to a decrease in the concentration of attention. That is why it is better to refrain from long trips.

Cost

Pentalgin price varies from 75 to 195 rubles. For one package. The drug is released without a recipe. Available in all pharmacies.

LSR-005571 / 10-170610

Trade name of the drug: Pentalgin®

Dosage form:

Tablets covered with film shell.

Composition on one tablet.
Active substances: Paracetamol - 325 mg, naproxen - 100 mg, anhydrous caffeine - 50 mg, Drochlorine hydrochloride - 40 mg, pheniramine Maleat - 10 mg.

Excipients:
Core: Cellulose microcrystalline, starch potato, croscarmello sodium, hypolosis (hydroxypropylcellulose (club EF)), lemon acid monohydrate, butylhydroxitoluluole (E 321), magnesium stearate, talc, chinoline yellow dye (E 104), indigormine (E 104).
Shell: HalpRellos (hydroxypropylmethylcellulose), povedium (polyvinylpyrrolidone Medium molecuular medical), polysorbate-80 (Twin-80), titanium dioxide, talc, chinoline yellow dye, indigormine (E 132). Description: Tablets covered with film shell from light green to green, double-screw in the form of a capsule with beveled edges, with a risk on one side and embossed Pentalgin to another. On the cut tablet light green with white splashes.

Pharmacotherapeutic Group:

Analgesic (analgesic nonarcotic agent + Nonteroid anti-inflammatory drug + psychostimulating agent + antispasmodic means + H1-histamine receptors blocker). ATX code: N02BE71

Pharmacological properties

The combined drug, has an analgesic, anti-inflammatory, antispasmodic, antipyretic effect.

Paracetamol is a non-carcotic analgesic, having an antipyretic and analgesic effect due to the cycloxygenase blockade in the central nervous system and the effect on pain and thermoregulation centers. Nonsproxen - Nonteroid anti-inflammatory drug, has an anti-inflammatory, analgesic and antipyretic effect associated with the non-selective suppression of cyclooxygenase activity regulating the synthesis of prostaglandins.

Caffeine - causes the expansion of blood vessels of skeletal muscles, hearts, kidneys; increases mental and physical performance, contributes to the elimination of fatigue and drowsiness; Increases the permeability of histohematic barriers and increases the bioavailability of non-scientific analgesics, thereby contributing to the strengthening of the therapeutic effect. It has a tonic effect on the brain vessels.

DROTAVERIN - has a myotropic antispasmodic effect due to the inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, urogenital and vascular systems.

Pheniramin - Blocator H1-histamine receptors. It has a spasmodic and light sedative effect, reduces the exisudation phenomena, and also enhances the analgesic effect of paracetamol and naproxen.

Indications for use
Painful syndrome of various genesis, including with pain in the joints, muscles, radiculitis, menstrual pains, neuralgia, dental and headaches (including the headache caused by the spasm of the brain vessels).

The pain syndrome associated with the spasm of smooth muscles, including in chronic cholecystitis, gallstone disease, postcholycistectomic syndrome, renal colic.

Post-Stramatic and postoperative pain syndrome, including accompanied by inflammation.

Walled diseases accompanied by feverish syndrome (as symptomatic therapy).

Contraindications
Increased sensitivity to the components of the drug, erosive-ulcerative lesions of the gastrointestinal tract (in the exacerbation phase), gastrointestinal bleeding, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and the incomplete sinuses and intolerance of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including history, heavy hepatic and / or renal failure, inhibition of bone marrowing, condition after the aorto-coronary shunting; Heavy organic diseases of the cardiovascular system (including acute myocardial infarction), paroxysmal tachycardia, frequent ventricular extrasystole, severe arterial hypertension, hypercalemia, child age up to 18 years, pregnancy and lactation period.

Carefully - cerebrovascular diseases, diabetes, peripheral arterial diseases, ulcerative lesions of the gastrointestinal tract in history, renal and liver failure of light or medium severity, viral hepatitis, alcohol liver damage, benign hyperbilirubinemia (Zhilbera, Dubbi-Johnson syndrome and rotor), Epilepsy and tendency to convulsive supplies, glucose-6-phosphate dehydrogenase deficiency, elderly age.

If you have one of the listed diseases / conditions, before taking the drug, be sure to consult your doctor.

Method of application and dose

Inside. The drug takes 1 tablet 1-3 times a day. Maximum daily dose - 4 tablets.

The duration of treatment is not more than 3 days as an antipyretic agent and no more than 5 days - as an anesthetic. Continuation of treatment with the drug is possible only after consulting a doctor. Do not exceed the specified dose!

Side effect
Allergic reactions: skin rash, itching, urticaria, angioedema, edema;

From the part of the blood formation organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;

From the nervous system: excitation, anxiety, reinforcement of reflexes, tremor, headache, sleep disorders, dizziness, reduction of attention concentration;

From the side of the cardiovascular system: heartbeat, arrhythmia, an increase in blood pressure;

From the digestive system: erosive-ulcerative lesions of the gastrointestinal tract, nausea, vomiting, discomfort in epigastria, abdominal pain, constipation, violation of the liver function;

From the urinary system: violation of kidney function; From the sides of the senses: a decrease in hearing, the noise in the ears, an increase in intraocular pressure in patients with a closedian glaucoma;

Others: Dermatitis, Tahipnee (Breathing).

If any of the side effects specified in the instructions are exacerbated, or you notice any other side effects that are not listed in the instructions, report this to the doctor.

Overdose

Symptoms: Pallor of skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, excitation, motor anxiety, confusion, tachycardia, arrhythmia, hyperthermia (body temperature increase), rapid urination, headache, tremor or muscular twitching; Epileptic seizures, increasing the activity of "liver" transaminases, hepathonecosis, increasing prothrombin time. Symptoms of the liver function may appear 12-48 hours after overdose. In severe overdose, hepatic insufficiency is developing with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. When suspected overdose, it is necessary to immediately apply for medical help.

Treatment: stomach wash with subsequent intake of activated carbon. Specific antidote in paracetamol poisoning is acetylcysteine. The introduction of acetylcysteine \u200b\u200bis relevant for 8 hours. In gastrointestinal bleeding it is necessary to introduce antacid agents and washing the stomach with an ice-cold 0.9% sodium chloride solution; maintaining ventilation of lungs and oxygenation; with epileptic seizures - intravenous administration of diazepam; Maintaining the balance of fluid and salts.

Interaction with other medicines
Simultaneous reception of the drug with barbiturates, tricyclic antidepressants, rifampicin and alcohol drinking beverages should be avoided (the risk of hepatotoxic action increases).

Paracetamol enhances the effect of indirect effect anticoagulants and reduces the effectiveness of uricosuric drugs.

Long use of barbiturates reduces paracetamol efficiency. The simultaneous use of paracetamol with ethanol increases the risk of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of paracetamol hepatotoxic effect.

Difluunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Naproxen can cause a decrease in the diuretic effect of furosemide, strengthening the effect of indirect anticoagulants, increases the toxicity of sulfanimamides and methotrexate, reduces lithium removal and increases its concentration in blood plasma.

With the joint use of caffeine and barbiturates, prison, anticonvulsants (Derivatives of Gidantoin, especially phenytoin), it is possible to strengthen the metabolism and an increase in caffeine clearance; With simultaneous reception of caffeine and cimetidine, oral contraceptives, disulfyram, ciprofloxacin, norfloxacin - decrease in caffeine metabolism in the liver (slowing down its removal and increase in blood concentration). The simultaneous use of caffene-containing drinks and other means stimulating the central nervous system can lead to excessive stimulation of the central nervous system.

With the simultaneous use of DROTAVERINA can weaken the anti -archinkinsonic effect of Levodopa.

With the simultaneous use of pheniramine with tranquilizers, sleeping pills, monoaminoxidase inhibitors, alcohol can enhance the inhibitory effect on the central nervous system.

special instructions
The simultaneous use of the drug with other means containing paracetamol and / or other non-steroidal anti-inflammatory drugs should be avoided, as well as with means to facilitate the symptoms of "cold", flu and nasal congestion.

When applying the drug, more than 5-7 days should be monitored by the performance of peripheral blood and the functional state of the liver. Paracetamol distorts the results of laboratory studies of the content of glucose and uric acid in the blood plasma.

If necessary, the determination of 17-ketosteroids the drug should be canceled 48 hours before the study. It should be borne in mind that the naproxen increases the bleeding time.

The effect of caffeine on the central nervous system depends on the type of nervous. Systems and can manifest themselves both excitation and braking of higher nervous activity.

During the treatment period, alcohol-containing drinks should not be used. In some cases, it is possible to reduce the concentration of attention and the velocity of psychomotor reactions, so during the period of treatment it is necessary to abide by the driving of vehicles and the occupation of other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release
Tablets covered with film shell.
2, 10 or 12 tablets into the contour cellular packaging from the film of polyvinyl chloride and foil aluminum printed lacquered.
1 or 2 Contour cell packaging along with instructions for use in a pack of cardboard.

Storage conditions
In a dry, light-protected place at a temperature not higher than 25 ° C.
Keep out of the reach of children.

Shelf life
2 years. Do not use the expiration date specified on the package.

Conditions of vacation from pharmacies
Without recipe.

The name and address of the manufacturer / organization that accepts claims:
Pharmstandart-Lexers OJSC 305022, Russia, Kursk, ul. 2nd aggregate, d. 1 A / 18
Pharmstandart-Tomskhimfarm OJSC 634009, Russia, Tomsk, Lenin Ave., 211