Take calcium d 3. Complivit calcium D3. When the drug is prescribed

Instructions for use:

Calcium-D3 Nycomed is a regulator of calcium-phosphorus metabolism, which compensates for the lack of calcium and vitamin D3 in the body.

Calcium-D3 Nycomed belongs to the pharmacological groups of correctors of the metabolism of cartilage and bone tissue in combinations, vitamins and vitamin-like agents in combinations.

pharmachologic effect

Calcium-D3 Nycomed is a preparation of a combination of calcium and vitamin D3 (cholecalciferol), it is necessary in the case of:

Regulation of phosphorus-calcium metabolism;
Replenishment of calcium deficiency in hair, teeth, muscles, bones, nails;
Decrease in resorption (resorption) and increase in bone density;
Replenishment of the deficiency of calcium and vitamin D3, necessary for the mineralization of teeth;
Regulation of muscle contractions, nerve conduction;
Normalization of blood clotting;
Decrease in the production of parathyroid hormone, which stimulates the leaching of calcium from the bones.

Vitamin D3 in the preparation helps to increase the absorption and distribution of calcium in tissues and organs. Entering the body, the components of the drug are absorbed by the gastrointestinal tract: vitamin D3 - by the small intestine, calcium - by the proximal part of the small intestine. The biological availability of calcium in the preparation Calcium-D3 Nycomed is about 30%. In the extracellular space and inside cells, about 1% of calcium is distributed, the rest of the calcium is distributed into the bone tissue. Vitamin D3 is partially metabolized by the liver, turning into calcitriol (an active metabolite).

The active components of the drug are excreted from the body through the kidneys and the gastrointestinal tract, additionally calcium is excreted through the sweat glands.

Release form Calcium-D3 Nycomed

Calcium-D3 Nycomed - round chewable tablets, white, biconvex, without a shell, uneven edges and small blotches are possible:

Orange flavored tablets - 20, 50, 100 pieces. Plastic bottle in a cardboard box;
Tablets with menthol flavor - 20, 50, 100 pieces. Plastic bottle in a cardboard box;
Lemon-flavored tablets (Calcium-D3 Nycomed Forte) - 30, 60, 120 pieces. Plastic bottle in a cardboard box.

Analogs Calcium-D3 Nycomed

Analogues of Calcium-D3 Nycomed in terms of the active component - Calcium + vitamin D3 Vitrum, Calcium-D3-MIC, Complivit calcium D3, Natekal D3, Revital Calcium D3, Calcium D3 Classic.

Analogs of the drug by the mechanism of action - Vitrum Osteomag, Calcohel (homeopathic), Calcemin, Calcemin Advance, Calcium-D3 Actavis.

Indications for use Calcium-D3 Nycomed

According to the instructions, Calcium-D3 Nycomed is prescribed for the treatment and prevention of a lack of calcium and vitamin D3 in the body in the case of:

Osteoporosis (menopausal, steroid, senile, idiopathic, etc.) for prevention and in combination with basic treatment;
Osteomalacia - softening of bones as a result of a violation of mineral metabolism;
Hypocalcemia - with a decrease in the content of ionized calcium in the blood serum;
The increased need of the body for the components of the drug is a period of intensive growth of children after 12 years.

Calcium-D3 Nycomed during pregnancy

According to the instructions, Calcium-D3 Nycomed during pregnancy and lactation is recommended to be taken to replenish the deficiency of vitamin D3 and calcium. Hypercalcemia due to drug overdose may adversely affect fetal development. The maximum daily dose of the components of the drug is 1500 mg of calcium, and 600 IU of vitamin D3.

The drug can be taken during lactation, but you should be aware that cholecalciferol and calcium can pass into breast milk. To calculate the daily dose of the drug, in this case, it is necessary to take into account other sources of intake of these components in the mother and child.

Calcium-D3 Nycomed during pregnancy and lactation should be taken only as directed by the attending physician and under his supervision.

Contraindications

According to the instructions, Calcium-D3 Nycomed is not prescribed in the case of:

Increased individual sensitivity to the components of the drug, peanuts and soybeans;
Hypervitaminosis D3;
Hypercalcemia;
Hypercalciuria;
Nephrotiliasis;
Severe renal failure;
Active form of tuberculosis;
Phenylketonuria;
Sarcoidosis;
Hereditary fructose intolerance;
Glucose-galactose malabsorption;
Sugar isomaltase deficiency.

With caution, Calcium-D3 Nycomed should be prescribed in case of moderate renal failure, involuntarily immobile patients, the elderly, children under the age of 12 years.

Method of application Calcium-D3 Nycomed

According to the instructions, Calcium-D3 Nycomed is taken orally, chewed or swallowed whole. Adults and children after 12 years of age 1 tablet 2 times a day in the morning and in the evening during meals or according to the scheme prescribed by the attending physician, taking into account the individual characteristics of the organism.

Drug interactions

According to the instructions, Calcium-D3 Nycomed, when taken simultaneously, interacts with such drugs as follows:

Cardiac glycosides - the drug potentiates the toxic effects of glycosides in hypercalcemia. It is necessary to control the content of calcium in the blood serum and ECG;
Tetracycline drugs - calcium reduces their absorption from the gastrointestinal tract. Tetracyclines should be taken 2 hours before or 4-6 hours after taking the drug;
Bisphosphonates - Calcium reduces their absorption. Take at least an hour before the drug;
GCS - reduce calcium absorption. An increase in the dose of the drug is possible;
Thiazide diuretics - increase the risk of hypercalcemia. Regular monitoring of serum calcium is required;
Levothyroxine - calcium reduces its absorption. The gap between doses of drugs is at least 4 hours;
Quinolone antibiotics - calcium reduces their absorption. Are taken 2 hours before or 4 hours after taking the drug.

Calcium absorption reduces the intake of foods containing oxalates and phytin. Therefore, according to the instructions, Calcium-D3 Nycomed can be taken 2 hours after eating cereals, spinach, sorrel, rhubarb.

Side effects

When taking Calcium-D3 Nycomed, according to reviews, stomach pain, nausea, diarrhea, flatulence, constipation are possible. Sometimes, uncontrolled drug use can cause hypercalcemia or hypercalciuria.

With a severe overdose of Calcium-D3 Nycomed, according to reviews, can cause thirst, polyuria, loss of appetite, nausea, vomiting, constipation, headache, weakness, dizziness, fainting. With prolonged use, the formation of vascular and tissue calcification is possible.

Storage conditions

Calcium-D3 Nycomed is stored at room temperature, in a dry place out of direct sunlight.

Shelf life - 3 years from the date on the package.

One tablet contains

active substances: calcium carbonate 1250 mg (equivalent to elemental calcium 500 mg), cholecalciferol 5.5 μg (200 IU vitamin D3) in the form of cholecalciferol concentrate * 2.20 mg.

excipients: xylitol 225mg, orange flavor granulate 55.9mg (containing isomalt 55.1mg, orange flavoring 0.839mg, mono- and diglycerides of fatty acids 0.000727mg), povidone 15.75mg, magnesium stearate 6.00mg, sucralose 0.25mg.

* cholecalciferol concentrate contains, including 10% excess: cholecalciferol 0.00550mg, DL-α-tocopherol 0.0220mg, triglycerides with an average chain length of 0.0660mg, modified corn starch 1.61mg, sucrose 0.385mg, sodium ascorbate 0.0880mg, silicon dioxide 0.0264mg.

Description

Round uncoated biconvex tablets of white color with orange flavor. May have small blotches and uneven edges.

Pharmacotherapeutic group

Mineral supplements. Calcium preparations. Calcium supplements in combination with other medications.

ATX code А12АХ

Pharmacological properties

Pharmacokinetics

Typically, the amount of calcium absorbed in the gastrointestinal tract (GIT) is approximately 30% of the dose taken.

99% of the calcium in the body is concentrated in the tough structure of bones and teeth. The remaining 1% is in intra- and extracellular fluids. About 50% of the total calcium in the blood is in a physiologically active ionized form, with about 10% in combination with citrate, phosphate or other anions, the remaining 40% associated with proteins, primarily albumin.

Calcium is excreted in feces, urine and sweat. Renal excretion depends on glomerular filtration and tubular calcium reabsorption.

Cholecalciferol

Vitamin D3 is easily absorbed in the small intestine.

Cholecalciferol and its metabolites circulating in the blood bind to a specific globulin. Cholecalciferol is converted in the liver by hydroxylation to 25-hydroxycholecalciferol. Then it is converted in the kidneys into the active form 1,25-dihydroxycholecalciferol. 1,25-dihydroxycholecalciferol is a metabolite that increases calcium absorption. Unmetabolized vitamin D3 is deposited in adipose and muscle tissues.

Vitamin D3 is excreted in feces and urine.

Pharmacodynamics

Combined drug that regulates the exchange of calcium and phosphorus in the body. Reduces resorption (resorption) and increases the density of the bone skeleton and teeth, replenishing the lack of calcium and vitamin D in the body.

Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.

Vitamin D3 increases intestinal absorption of calcium.

Calcium and vitamin D3 supplementation counteracts the increase in parathyroid hormone (PTH) levels caused by calcium deficiency and causing an increase in calcium leaching from the bones.

Indications for use

Prevention and treatment of calcium and vitamin D deficiency

Calcium and Vitamin D supplementation as adjunctive therapy for osteoporosis in patients at risk of calcium and vitamin D deficiency

Method of administration and dosage

Calcium and Vitamin D Deficiency:

Adults: One tablet one to three times a day.

Children: one tablet once or twice a day.

Adjunctive therapy for osteoporosis:

Adults and the elderly: one tablet two to three times a day.

Renal failure

Calcium-D3 Nycomed should not be taken in patients with severe renal impairment.

The tablet can be chewed and sucked.

Side effects

Adverse reactions are distributed according to the class of organ systems and the frequency of occurrence, which was classified as follows: infrequent (≥ 1/1000,< 1/100); редкие (≥ 1/10000, < 1/1000); очень редкие (< 1/10000), частота неизвестна (не может быть установлена на основании имеющихся данных).

Metabolic and nutritional disorders

Uncommon: hypercalcemia and hypercalciuria.

Very rare: lactic-alkaline syndrome (frequent urge to urinate; prolonged headache; prolonged loss of appetite; nausea or vomiting; fatigue or weakness; hypercalcemia, alkalosis, and renal failure). As a rule, it is observed in case of an overdose.

Gastrointestinal Disorders

Rarely: constipation, indigestion, flatulence, nausea, abdominal pain and diarrhea.

Skin and subcutaneous tissue

Very rare: itching, rash, and hives.

Patients with renal impairment: potential risk of hyperphosphatemia, nephrolithiasis, and nephrocalcinosis.

From the immune system

Not known: hypersensitivity reactions such as Quincke's edema or laryngeal edema.

After initiation of drug treatment, all suspected side effects should be reported. This allows you to continuously monitor the profile of the benefit / risk ratio of the drug.

Contraindications

Hypersensitivity to active substances or excipients

Severe renal failure (glomerular filtration rate<30 мл/мин /1.73m2)

Diseases and / or conditions causing the development of hypercalcemia and / or hypercalciuria

Kidney stone disease (nephrolithiasis)

Vitamin D hypervitaminosis

Calcium-D3 Nycomed contains isomalt (E953) and sucrose. Therefore, patients with rare hereditary problems of fructose intolerance, impaired absorption of glucose-galactose and sucrose-isomaltase deficiency should not take this drug.

Drug interactions

Thiazide diuretics reduce urinary calcium excretion. Due to the increased risk of hypercalcemia, it is necessary to regularly monitor serum calcium levels during concomitant use of thiazide diuretics.

Hypercalcemia can increase the toxicity of cardiac glycosides during calcium and vitamin D treatment. Patients should be monitored by electrocardiography (ECG) and serum calcium levels should be monitored.

Calcium carbonate can affect the absorption of concomitantly taken tetracycline drugs. For this reason, tetracycline drugs should be taken at least two hours before or four to six hours after oral administration of calcium carbonate.

The absorption of quinolone antibiotics can be impaired when taken simultaneously with calcium. Quinolone antibiotics should be taken two hours before or six hours after taking calcium supplements.

With the concomitant use of bisphosphonates, these drugs must be taken at least one hour before taking Calcium-D3 Nycomed, since absorption in the gastrointestinal tract may be reduced.

The effectiveness of levothyroxine may decrease with the simultaneous use of calcium, due to a decrease in the absorption of levothyroxine. At least four hours should elapse between calcium and levothyroxine intake.

Calcium salts can reduce the absorption of iron, zinc and strontium ranelate. Therefore, iron, zinc, or strontium ranelate supplements should be taken at least two hours before or after calcium supplementation.

Orlistat treatment can potentially interfere with the absorption of fat-soluble vitamins (eg vitamin D3).

special instructions

During long-term treatment, serum calcium levels should be monitored and renal function monitored by measuring serum creatinine levels. Monitoring is especially important in elderly patients with concomitant treatment with cardiac glycosides and diuretics, and in patients with an increased tendency to form stones. In cases of hypercalcemia or signs of impaired renal function, the dosage should be reduced or treatment discontinued.

Calcium carbonate with cholecalciferol should be used with caution in patients with hypercalcemia or signs of impaired renal function, and the effect of calcium and phosphate should be monitored. The risk of soft tissue calcification must be taken into account.

In the course of concomitant therapy with other sources of vitamin D and / or drugs or nutrients containing calcium, there is a risk of hypercalcemia and lactic acid syndrome, followed by impaired renal function. In such patients, serum calcium levels and renal function should be monitored.

Calcium-D3 Nycomed should be prescribed with caution to patients suffering from sarcodiosis, due to the risk of increased conversion of vitamin D into its active form. In such patients, serum and urine calcium levels should be monitored.

Calcium-D3 Nycomed should be administered with caution to immobilized patients with osteoporosis, due to the risk of hypercalcemia.

In hepatic impairment, dose adjustment is not required.

Pregnancy and lactation

Pregnancy

Calcium-D3 Nycomed can be used by women during pregnancy in case of calcium and vitamin D deficiency.During pregnancy, the daily dose should not exceed 2500 mg of calcium and 4000 IU of vitamin D. But an overdose of calcium and vitamin D in pregnant women should be avoided, since constant hypercalcemia adversely affects the developing fetus.

Vitamin D in therapeutic doses does not have a teratogenic effect.

Lactation period

Calcium-D3 Nycomed can be used during breastfeeding. Calcium and vitamin D3 pass into breast milk. This should be taken into account in cases of additional administration of vitamin D to a child.

In the case of diagnosed calcium deficiency in the body, the drug of choice for most patients is "Calcium D3 Nycomed". The original product is manufactured by a Norwegian pharmaceutical company registered under the name Nycomed Pharma AS. The price of the drug depends on the number of tablets and starts at 225 rubles. You can buy the supplement without a prescription at any pharmacy.

Calcium D3 Nycomed is available as a soft chewable tablet.

Number of pieces in a polyethylene package:

with flavor additive "orange" - 20, 50, 100 pieces;
"Mint" - 30, 100 pieces.

The main active ingredient of the product is calcium carbonate, contained in tablets in an amount of 1250 mg. Vitamin D3 (colicalciferol) (5 μg) promotes better absorption of the trace element. As auxiliary components, the composition contains elements such as sorbidol, aspartame, povidone. Orange or mint oil is responsible for the taste and aroma characteristics of chewable tablets.

What is Calcium d3 Nycomed prescribed for?

The principle of action of the agent is to regulate calcium-phosphorus metabolism. As a result of the intake, the bones become denser and stronger, the teeth are mineralized. The trace element is involved in the process of blood coagulation, hormone production, improves the condition of muscle tissue, regulates the sensitivity of nerve cells. The presence of vitamin D3 in the composition is explained by the need to increase the absorption of calcium and an obstacle to its leaching.

The drug is prescribed for such violations:

lack of calcium;
hypovitaminosis of vitamin D3;
osteoporosis of various etiologies;
insufficient bone strength;
thinning of tooth enamel;
frequent bone fractures.

In the digestive organs, only 30% of the microelement is absorbed. The active ingredient enters the bones and teeth, binds to albumin. The excretion of decay products is carried out through the kidneys and digestive organs, as well as with the release of sweat.

Instructions for the use of the medicinal product

Before taking "Calcium D3 Nycomed", it is strongly recommended to read the instructions. It is located under the adhesive label on the jar. Chewable tablets should be taken directly with food or after, by chewing or dissolving.

The dosage depends on the age:

3-5 years - determined individually by the pediatrician based on the test results;
5 - 12 years old - 1 - 2 pcs. in a day;
from 12 years old - 1 pc. 2 p. in a day.

For patients over 60 years of age, patients with liver and kidney pathologies, dose adjustment is not performed.

If the drug is used to prevent hypocalcemia or vitamin D3 deficiency, the dosage and duration of the course of medication is determined by a specialist. With a lack of calcium, the duration of therapy is 4 to 6 weeks.

Application during pregnancy and lactation

Women are advised to use "Calcium D3 Nycomed" during pregnancy to correct the lack of this microelement and vitamin D3. The maximum dose of calcium is 1500 mg per day. The recommended dose should not be exceeded, because the development of hypercalcemia can have a negative effect on the condition of the fetus.

During breastfeeding, the use of the drug is not contraindicated, but the intake of the trace element with food should be taken into account, because the active components of the drug in a small amount penetrate into the mother's milk.

Drug interactions

"Calcium D3 Nycomed" has the ability to reduce the absorption of drugs from the gastrointestinal tract from the following pharmacokinetic categories:

tetracyclines;
bisphosphonates;
levothyroxines;
antibiotic agents of the quinolone group.

If therapy is carried out with the use of glucocorticosteroids, an increase in dosage may be necessary, since drugs from this category impair calcium absorption.

When taking thiazide diuretics together with the drug "Calcium D3 Nycomed Forte", it is necessary to monitor the level of a trace element in the blood serum, since the risk of developing the opposite to the deficit of the phenomenon, hypercalcemia, increases.

Contraindications, side effects and overdose

Taking the drug "Calcium D3 Nycomed" is rarely accompanied by unpleasant manifestations. In some cases, patients may be disturbed by symptoms from the gastrointestinal tract, in particular, flatulence, nausea, pain in the abdomen. Before starting the course, you must consult with a specialist and carefully read the instructions.

There are such contraindications to the use of the medicine:

hypercalcemia (high levels of calcium in the body);
hypercalciuria (exceeding the norm of the content of a trace element in the urine);
vitamin D hypervitaminosis;
nephrolithiasis;
active tuberculosis;
severe forms of kidney and liver pathologies;
phenylketonuria;
sarcoidosis;
age up to 3 years;
sensitivity to the constituents of the drug, as well as to soy, peanuts and fructose.

Exceeding the dosage for a long period has a toxic effect on the patient's condition. As a result of the accumulation of excess calcium, a sharp decrease in body weight occurs, up to the development of anorexia. The patient is accompanied by irritability, dizziness, constipation, muscle pain, emotional and mental state worsens, mental disorders may appear.

Due to the regular intake of tablets at a dose above 2500 mg, calcification of soft tissues develops, pathological processes in the kidneys become irreversible.

If an overdose is suspected, action should be taken immediately. First, you should stop taking the drug, as well as diuretics and cardiac glycosides. Secondly, go to a medical institution, where the patient will be given gastric lavage and medications that will reduce the absorption of calcium.

Analogues of Calcium d3 Nycomed

The pharmaceutical market offers a wide range of analogs of the original drug "Calcium D3 Nycomed". They may differ slightly in composition, price, but the principle of operation is usually the same.

Name	Application features	Manufacturer (country)	Release form	Price, rub.)
"Complivit calcium D3"	effectiveness decreases when taken together with phenytoin and barbiturates	Pharmstandard-UfaVITA (Russia)	chewable tablets (30 pcs.)	from 135
"Natekal D3"	takes part in the regulation of calcium-phosphorus metabolism	Italfarmako S.p.A. (Italy)	chewable tablets (60 pcs.)	from 361
"Vitrum Osteomag"	prescribed to patients aged 8 years and older, should be used with caution in patients with kidney disease	Unipharm Inc. (USA)	tablets (30 pcs.)	from 382
"Kalcemin Advance"	contains a whole complex of vitamins and minerals	Sagmel Inc. (USA)	tablets (30 pcs.)	from 418
"Calcium + vitamin D3"	is highly effective in the treatment of osteoporosis	Unipharm Inc. (USA)	coated tablets (30 pcs.)	from 254

Calcium deficiency is a common disorder, accompanied by such manifestations as fragility of bones and teeth, poor blood clotting, problems in the functioning of the digestive tract. When taking calcium supplements, it is important to strictly observe the dosage and follow the instructions of the attending physician, because an excess of this trace element also has a negative effect on the state of the body.

Composition of 1 chewable tablet:

- 1250 mg (in terms of elemental calcium - 500 mg);
cholecalciferol - 5.0 μg, which corresponds to 200 international units;
- 390 mg;
isomalt - 62.0 mg;
povidone - 36.4 mg;
magnesium stearate - 6.00 mg;
- 1.0 mg;
orange oil in the amount of 0.97 mg or mint flavoring additive weighing 31.9 mg;
mono and diglycerides of fatty acids - 0.0008 mg.

Composition Calcium D3 Nycomed Forte(1 tablet to chew):

calcium carbonate - 1250 mg (equivalent to 500 mg of elemental calcium);
vitamin D3 (cholecalciferol) - 10 mcg (400 IU);
sorbitol - 390 mg;
isomalt - 49.9 mg;
povidone - 36.4 mg;
magnesium stearate - 6 mg;
aspartame - 1.0 mg;
lemon oil - 0.78 mg;
mono and diglycerides of fatty acids - 0.0006 mg.

Release form

Orange or mint chewable tablets Calcium D3 Nycomed white, without a shell, biconvex, round with a corresponding aroma. The presence of small dotted inclusions and uneven edges is allowed. The tablets are packed in high-density polyethylene bottles of 20.50 or 100 pieces. The cardboard package contains 1 bottle with a medicinal product and an annotation to the preparation.
Calcium Nycomed D3 Forte- round chewable tablets with lemon flavor. Biconvex tablets are uncoated and are sold in high-density polyethylene bottles of 30, 60 and 120 pieces. 1 bottle and instructions for use of the drug are enclosed in a cardboard box.

pharmachologic effect

The drug belongs to combined pharmaceutical preparations that regulate the exchange of calcium and phosphorus in the body and compensate for the deficiency of the main structural element. The biochemical role of calcium lies in the physiological structure of bone tissue, mineralization of teeth, the processes of coagulation and transmission of nerve impulses, and the implementation of muscle contractions. In response to its increase in the systemic circulation, bone density increases, and calcium excretion by the kidneys decreases.

Cholecalciferol is responsible for the processes of absorption of the element in the gastrointestinal tract and its distribution in the body. Oral administration of the drug inhibits synthesis parathyroid hormone - a natural hormone of the parathyroid gland, which significantly affects the phosphorus-calcium metabolism. Accordingly, the amount of absorbed calcium from the digestive tube increases and its resorption (leaching) from bones and other organs decreases.

Pharmacodynamics and pharmacokinetics

Calcium absorbed from the proximal digestive tube in an amount of 30% of the dose taken, after which the element enters the systemic circulation, where 50% is in an active ionized form, that is, the active substance binds to citrates, phosphates, and some other anions and protein structures. The main building component is eliminated by the intestines, sweat glands and kidneys. When calculating excretion, it should be borne in mind that renal excretion of calcium depends not only on glomerular filtration, but also on tubular reabsorption.

Vitamin D3 absorbed mainly from the small intestine, from where about 80% of the dose taken enters the main bloodstream, where it binds to a specific transport globulin. Cholecalciferol metabolism includes two stages - first, the vitamin is converted by hydroxylation into 25-hydroxycholecalciferol, after which, entering the kidneys, it is transformed into an active form - 1,25-hydroxycholecalciferol ... The unchanged vitamin is stored by the body in muscle and adipose tissue. Cholecalciferol is excreted through the intestines and by the way.

Indications for use

prevention and complex treatment ;
deficiency of calcium and / or vitamin D3;
bone fractures.

Contraindications

Absolute contraindications to the use of a pharmaceutical product:

hypervitaminosis D;
hypercalcemia - increased calcium in the blood;
hereditary fructose intolerance;
immobilized patients;
hypercalciuria - the appearance of calcium in the urine;
glucose-galactose malabsorption;
nephrolithiasis and other diseases, in the pathogenesis of which the formation of calcium calculi is noted;
active form ;
sucrose-isomaltase deficiency;
increased sensitivity to the constituent components of the medicinal product or to such food products as soybeans and peanuts;
children up to age 3 years.

Side effects

From the side metabolism: hypercalcemia and hypercalciuria.
From the side gastrointestinal tract: (constipation ), flatulence , , nausea , abdominal pain , .
From the side skin and subcutaneous tissue: rash , , .

Instructions for Calcium D3 Nycomed (Method and dosage)

The instructions for use of the pharmaceutical preparation indicate that the drug is used orally, and the tablets should be chewed or sucked during meals. For prevention osteoporosis the dosage of Calcium D3 Nycomed is used: 1 tablet 2 times a day or 2 tablets 1 time a day. With the aim of complex therapy of this pathological condition, 1 tablet of Ca D3 Nycomed is taken 3 times a day. The duration of such treatment is prescribed individually, based on the biochemical parameters of metabolic processes and the state of bone tissue, teeth and skin derivatives (hair and nails).

To eliminate deficiency conditions the duration of the course of treatment is at least 4-6 weeks, and the dosage must take into account the age category of the patient:

children from 3 to 5 years old - 1 or ½ tablet per day;
from 5 to 12 years old - 1-2 tablets per day;
adults and adolescents over 12 years old - 1 tablet 2 times a day.

The instruction on Calcium D3 Nycomed Forte differs only in the dosage of the drug and the duration of the course of conservative therapy, therefore, when prescribing it, these aspects of the drug correction of phosphorus-calcium metabolism should be additionally discussed with the attending physician.

Overdose

In the event of an overdose of a pharmaceutical drug, symptoms develop that indicate hypercalcemia :

anorexia ;
dry mouth, thirst;
muscle weakness;
nausea and other dyspeptic disorders;
polyuria ;
bone pain;
mental disorders;
nephrocalcinosis ;
(with a prolonged increase in the concentration of calcium in the blood);
(in especially severe cases);
calcification of soft tissues;
organic kidney damage.

When symptoms of overabundance are detected calcium and vitamin D3 you should immediately stop taking the pharmaceutical product, Tiazide diuretics and cardiac glycosides (features of the pharmacokinetics of therapeutic properties are indicated in the "Interactions" section) and consult your doctor. As a rule, loop diuretics are prescribed for therapeutic purposes (the drug of choice is ), oral glucocorticosteroids, , bisphosphonates. In case of an overdose, the following physiological indicators must be monitored:

the content of electrolytes in blood plasma;
functional ability of the kidneys and diuresis;
central venous pressure;
electrical activity of the heart.

Interaction

With the combined use of Calcium D3 Nycomed and cardiac glycosides it is possible to potentiate the toxic effect of the latter, therefore, if it is necessary to use them simultaneously, careful monitoring of electrocardiography and the concentration of calcium in the blood is recommended.

Calcium can reduce absorption capacity group quinoline and a number of , and , bisphosphonates , therefore, these drugs should be taken no earlier than 2 hours before or 6 hours after the use of drugs based on the physiological "builder" of the body's skeletal system.

Glucocorticosteroids , barbiturates ,laxatives , phenytoin and reduce the bioavailability of an oral therapeutic agent, that is, the active components are absorbed in the gastrointestinal tract in smaller quantities, therefore it is necessary to correct the dosage or regimen of Calcium D3 Nycomed during conservative sanitation, involving a combination of the drug with other pharmaceutical products.

Thiazide diuretics in pharmacy, they are sometimes called saving ones, since pharmaceuticals of this series inhibit the tubular reabsorption of calcium and some other micro- and macroelements, as a result of which regular monitoring of serum calcium is required to avoid hypercalcemia and overdose conditions.

Use food products , which contain oxalates (sorrel, potatoes, spinach, rhubarb) or (most friable cereals), reduces the ability of calcium to be absorbed in the gastrointestinal tract, therefore, the daily diet should be adjusted in a special way. Do not take a pharmaceutical drug within four hours of eating any of the foods listed above.

Terms of sale

The sale of a pharmaceutical product implies OTC dispensing at pharmacy kiosks.

Storage conditions

Store the drug in a tightly closed bottle in a dry place out of the reach of children. Temperature range - no higher than 25 degrees Celsius.

Shelf life

special instructions

Brief information about the manufacturer

Nycomed is a Swiss pharmaceutical company founded back in 1874 with headquarters in Zurich, and is widely known for such medicinal products as, and Calcium D3 ... Until a certain time, it was one of the 30 largest corporations in the world in terms of sales in the market of conservative therapeutic agents. In September 2011, it was bought out by a Japanese company. Takeda, one of whose areas of interest is metabolic diseases and their correction with the help of drug treatment. Therefore, the official site of Nycomed is now represented by an Internet resource managed by Takeda.

The influence of a pharmaceutical product on the spheres of everyday life

Calcium D3 Nycomed is a combined drug with a marked selectivity of therapeutic action, that is, the active ingredients of chewable tablets and their auxiliary components do not affect the ability to concentrate, prolonged attention or other areas of everyday life. During the course of treatment, self-driving vehicles and work with technical complex mechanisms are allowed.

Analogs Calcium D3 Nycomed

Matching ATX level 4 code:

The drug belongs to the group of combined drugs for regulating the calcium level in the blood and the content of the structural element in the tissues of the body. There are, of course, a variety of chewable tablet analogs. As a rule, preparations are represented directly by a biogenic component and excipients for a more complete realization of its therapeutic properties. So it should be noted:

- mainly used for children in the age group to prevent calcium deficiency;
Ideos - chewable tablets prescribed for senile, age-related osteoporosis or its occurrence due to menopause;
- used for idiopathic progressive calcium deficiency and its complications in the form of bone fractures or dental problems.

These drugs are prescribed if there are any absolute or relative contraindications to Calcium D3 Nycomed, for example, with increased sensitivity to its auxiliary components, in order to avoid or the development of adverse effects of conservative therapy. The price of analogs Calcium D3 Nycomed, as a rule, is higher, which gives a clear advantage to this pharmaceutical agent for the correction of phosphorus-calcium metabolism.

Calcemin or Calcium D3 Nycomed - which is better?

is one of the most popular analogs of Calcium D3 Nycomed. It is a combined pharmaceutical product, the composition of which includes calcium carbonate , vitamin D3 , copper and zinc oxide, manganese sulfate and sodium borate. Coated tablets are prescribed not only for disorders of phosphorus-calcium metabolism, but also to replenish the deficiency of some microelements , which have important biological significance for the normal functioning of the body.

Calcium dosage and cholecalciferol in Calcemin an order of magnitude less than in chewable tablets Calcium D3 Nycomed, which causes fewer side effects, a sharply reduced chance of overdose. But the composition of the drug also causes more long medication course therapy for, therefore, it is prescribed mainly for adolescent children and women during pregnancy or during lactation. Calcium D3 Nycomed, in turn, copes much more effectively with its main task - the regulation of phosphorus-calcium metabolism and the elimination of the corresponding complications.

Calcium D3 Nycomed for children

In childhood, metabolic progressive diseases are especially difficult to tolerate, because the young organism is still at the stage of development and the reserve of compensatory-adaptive mechanisms has not yet been fully formed. Deficiency of calcium and vitamin D is one of the most pressing problems described by pediatric orthopedics, because as a result of this pathological insufficiency, a large number of severe nosological units can form up to mental and physical developmental delays , therefore, it is so important to undergo regular medical examinations and correct all diagnosed violations in a timely manner.

How to take Calcium D3 Nycomed for children should be found out exactly from the attending pediatrician, because its dosage is selected individually, taking into account the current blood calcium level, concentration parathyroid hormone and some other biochemical parameters.

The standard scheme of conservative therapy provides for the appointment of 1 tablet 1-2 times a day at the age of 5 to 12 years, and for adolescents over the age of 12 years - 1 chewable tablet 1-3 times a day. It should be understood that an overabundance of a pharmaceutical preparation, as well as its shortage, can lead to adverse consequences described in the "Overdose" section.

With alcohol

Alcohol abuse is a common cause deficiency conditions , since alcohol contributes to the leaching of micro- and macroelements, as well as vitamin structures from tissues and organs, therefore bad habits should be completely excluded during the period of a conservative course of treatment with calcium-based chewable tablets. As a preventive measure, it is recommended to significantly limit the proportion of alcoholic beverages, caffeine and smoking in the future.

Calcium D3 Nycomed during pregnancy and lactation

Lack of micro- and macroelements for pregnant women is a common condition, because a woman's body not only provides its own needs, but also supplies the necessary structural "bricks" for the normal organization of the tissues and organs of the child. It is especially often manifested calcium deficiency - one of the main components of the skeleton, muscular organs and the nervous system, but it is rather difficult to assimilate, therefore it is recommended to use special drugs that compensate for the state of insufficiency. Medicines are prescribed if the following symptoms of calcium deficiency are observed during pregnancy:

back pain;
numbness of the upper and lower extremities;
hair loss and brittle nails;
tooth decay;
leg cramps.

Calcium D3 Nycomed during pregnancy is the drug of choice for replenishing the deficiency of a structural element in the mother's body. First of all, the drug in a relatively short time allows you to eliminate the lack of calcium and restore pathologically altered body functions. It should also be noted that the oral form of chewing tablets is more physiological and, to a lesser extent, may cause any side effects or adverse consequences for the woman and her unborn child.

Calcium D3 Nycomed tablets can be used with breastfeeding , however, it should be borne in mind that the active components of the pharmaceutical preparation have the ability to penetrate into breast milk during lactation, and therefore it is necessary to accurately correlate other sources of calcium and vitamin D intake in the newborn's body. When prescribing Calcium D3 Nycomed to young mothers, you should definitely find out the symptoms hypervitaminosis and hypercalcemia in a small child, in order to stop using the drug in time.

Calcium-D3 Nycomed

Composition

1 tablet of chewable preparation Calcium-D3 Nycomed contains:

Cholecalciferol - 200MO;

1 tablet of chewable preparation Calcium-D3 Nycomed Forte contains:
Calcium carbonate - 1250 mg (in terms of calcium - 500 mg);
Cholecalciferol - 400MO;
Excipients, including aspartame.

pharmachologic effect

Combined preparation containing calcium and cholecalciferol (vitamin D3). The drug regulates phosphorus-calcium metabolism, replenishes calcium deficiency in the body. Calcium is involved in the formation of bone tissue, mineralization of teeth and bones, blood coagulation processes, as well as the transmission of nerve impulses.
Taking the drug prevents excessive synthesis of parathyroid hormone, which enhances bone resorption. Cholecalciferol regulates the absorption of calcium in the gastrointestinal tract, as well as the distribution of calcium in the body.
After oral administration, the active components of the drug are well absorbed in the gastrointestinal tract. Cholecalciferol is absorbed in the small intestine, calcium in the proximal small intestine. The bioavailability of calcium is about 30%. Cholecalciferol is partially metabolized in the liver to form pharmacologically active metabolites. About 1% of calcium is found inside cells and in the extracellular space, the rest is concentrated in bone tissue. Calcium is a part of complex compounds and proteins, about 50% is in ionized form. The active components of the drug are excreted by the intestines and kidneys, in addition, calcium is excreted through the sweat glands.

Indications for use

The drug is used for the prevention of osteoporosis, as well as for the prevention and treatment of calcium and / or cholecalciferol deficiency.
The drug will be prescribed as part of complex therapy for patients suffering from osteoporosis of various etiologies.

Mode of application

Chewable tablets Calcium-D3 Nycomed:
The drug is intended for oral administration. The tablet is allowed to be swallowed whole, divided or chewed. The drug is taken regardless of food intake. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
Adults and adolescents over the age of 12 years are usually prescribed 1 tablet of the drug 1-3 times a day in order to prevent calcium and cholecalciferol deficiency.

Adults and adolescents over the age of 12 with osteoporosis are usually prescribed 1 tablet of the drug 2-3 times a day.

Chewable tablets Calcium-D3 Nycomed Forte:
The drug is intended for oral administration. The tablet is swallowed whole or chewed with a small amount of liquid. The drug is taken regardless of food intake. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient:
Adults and adolescents over the age of 12 years for the purpose of prevention, as well as in the complex therapy of osteoporosis are usually prescribed 1 tablet of the drug 2-3 times a day.
Adults and adolescents over the age of 12 years are usually prescribed 1 tablet of the drug 2 times a day in order to prevent calcium and cholecalciferol deficiency.
Children aged 5 to 12 years are usually prescribed 1 tablet of the drug 1-2 times a day in order to prevent calcium and cholecalciferol deficiency.
The duration of the course of taking the drug is usually 4 to 6 weeks. If necessary, the course of taking the drug is repeated several times a year.

Side effects

The drug is usually well tolerated by patients; in isolated cases, the development of such side effects was noted:
From the gastrointestinal cycle: stool disturbance, nausea, pain in the epigastric region, decreased appetite.
Allergic reactions: skin rash, itching, urticaria.
In addition, the development of hypercalcemia and hypercalciuria is possible.

Contraindications

Increased individual sensitivity to the components of the drug.
The drug is contraindicated in patients with phenylketonuria.
The drug is not prescribed for patients with hypervitaminosis D3, elevated levels of calcium in the blood plasma and / or urine, as well as urolithiasis with the formation of calcium calculi.
The drug is not used to treat patients with severe renal failure and sarcoidosis.
The drug is not prescribed for children under the age of 5 years.
The drug is prescribed with caution to patients with moderate renal insufficiency, immobilized patients, as well as elderly patients.

Pregnancy

The drug can be prescribed during pregnancy.
The maximum daily intake of calcium for women during pregnancy is 1500 mg, cholecalciferol is 600 MO.
When taking the drug during lactation, you should take into account the amount of calcium and vitamin D3, which enter the organisms of the mother and child with food.

Drug interactions

The combined use of the drug with other drugs containing calcium and cholecalciferol is contraindicated.
When used in combination, the drug enhances the absorption of tetracycline antibiotics. An interval of at least 3 hours should be observed between taking these drugs.
With simultaneous use, the drug reduces the absorption of sodium fluoride and bisphosphonates. An interval of at least 2 hours should be observed between taking these drugs.
Phenytoin and barbiturates, when used simultaneously with the drug, reduce the pharmacological effects of vitamin D3.
If necessary, the simultaneous use of the drug with drugs of the group of cardiac glycosides, the patient's condition and ECG should be monitored.
Combined use of corticosteroids reduces intestinal absorption of calcium.
Laxatives and cholestyramine, when combined with the drug, reduce the absorption of vitamin D3.
Thiazide diuretics reduce calcium excretion from the body, loop diuretics increase it. If it is necessary to use the drug in combination with diuretics, the level of calcium in the blood plasma should be monitored.

Overdose

With the use of overestimated doses of the drug, as well as with prolonged use of the drug in doses exceeding the recommended ones, patients may develop hypercalcemia, the symptoms of which are nausea, vomiting, loss of appetite, dizziness, headache, weakness. In addition, the development of hypercalciuria, an increase in the level of creatinine in the blood, and coma are also possible. The development of polyuria and polydipsia are signs of possible kidney damage caused by drug overdose.
In case of an overdose, discontinuation of the drug is indicated, the introduction of a large amount of fluid into the body, as well as a diet with a low calcium content. In case of a severe overdose of the drug, specific therapy is indicated, including glucocorticosteroids.

Release form

Chewable tablets Calcium-D3 Nycomed with orange flavor, 20, 50 or 100 pieces in polymeric bottles, 1 bottle in a cardboard box.
Chewable tablets Calcium-D3 Nycomed with mint flavor, 20, 50 or 100 pieces in polymeric bottles, 1 bottle in a cardboard box.
Chewable tablets Calcium-D3 Nycomed Forte, 30, 60 or 120 pieces in bottles of polymeric materials, 1 bottle in a cardboard box.

Storage conditions

The drug is recommended to be stored in a dry place away from direct sunlight at a temperature of 15 to 25 degrees.
The shelf life of the drug, regardless of the form of release, is 3 years.

Authors

Links

Official instruction for the drug Calcium-D3 Nycomed.

Attention!
Description of the drug " Calcium-D3 Nycomed"on this page is a simplified and updated version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and familiarize yourself with the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the doses and methods of its use.